Navneet Kumar Verma*1, Abhay Pratap Singh1, Shobhit Prakash Srivastava2
1Department of Pharmacy, Kailash Institute of Pharmacy and Management, GIDA, Gorakhpur, Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, U.P, India.
2Dr. M.C. Saxena College of Pharmacy, Lucknow, Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, U.P, India.
A B S T R A C T
Streblus asper L. is a small tree found in tropical countries, such as India, Sri Lanka, Malaysia, the Philippines and Thailand belonging to family moraceae. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as filariasis, leprosy, toothache, diarrhea, dysentery and cancer. Research carried out using different in vitro and in vivo techniques of biological evaluation support most of these claims. The role of oxidative stress in the pathophysiology of diabetes and its associated complications are well known. The antioxidant system plays an important role in defending the cells against oxidants generated during metabolic processes and thus prevents the tissues from toxic response of the oxidants. The methanol extract of Streblus asper exhibited anti diabetic property as well as increased the levels of enzymatic and non enzymatic anti oxidant entities along with reduced MDA levels. The methanol extract of this plant did not exhibit any toxicity in the present study and thus it was concluded that the extract possesses antidiabetic as well as antioxidant properties without any adverse effect. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal plant.
Keywords: antifilarial, cardiac glycosides, Moraceae, Shakhotaka, Streblus asper