Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore -524 346
A B S T R A C T
The present study was aimed to evaluate the phytochemical screening and in-vitro anti- inflammatory activity of ethanolic extract of Jatrophagossypifolia Linn. It reveals the presence of considerable amount of alkaloid, steroid, phenolic substances and vitamin C (Ascorbic acid), moderately saponins and carbohydrates, trace amount of glycoside and resins were explored from the phytochemical screening. The investigation is based on the need for newer anti-inflammatory agents from natural source with potent activity and lesser side effects as substitutes for chemical therapeutics. Realizing the fact this study was carried out to evaluate the in vitro anti-inflammatory activity of ethanolic extract of J. gossypifolia. Results of the study is obtained that the ethanolic extract of J. gossypifolia was exhibited membrane stabilization effect by inhibiting hypotonicity induced lysis of erythrocyte membrane in concentration dependent manner It is due to the presence of active principles such as flavonoids and tritrepenoids may responsible for this activity. Hence, J. gossypifolia can be used as a potent anti-inflammatory agent.
Keywords:Jatrophagossypifolia Linn, Anti-inflammatory activity, Phytochemical Screening, Ethanolic extract, Hypotonicity