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A New RP-HPLC method developed and validated for the estimation of Tolterodine

Gobalakrishnan P*1, Munisekhar V, Hemanth Kumar V 1Department of Pharmaceutical Analysis, Vagdevi College of Pharmacy & Research Centre, Nellore, Andhra Pradesh, India. A B S T R A C T A rapid and sensitive RP-HPLC Method with UV detection (283nm) for routine analysis of Tolterodine in Bulk and in Pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing ... Read More »

Synthesis, Characterization, Biological Evaluation and Docking studies of 2-(benzyl sulfonyl)-5-(3-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-1,3,4-oxadiazole Derivatives

G. Govindu*, D. Rajesh, P. Raveendra Reddy, L.K. Ravindranath Department of chemistry, Sri Krishnadevaraya University, Anantapuramu, A.P-India A B S T R A C T New novel derivatives of 2-((4- substituted benzyl)sulfonyl)-5-(3-(4-( substituted phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-1,3,4-oxadiazoles  (9a-l as per scheme-I)were prepared by condensation of 2-(4-hydrazinylpyrimidin-5-yl)-5-((4-substituted benzyl)sulfonyl)-1,3,4-oxadiazole (8a-f) with various 4-substituted benzoic acids. The synthon 8a-f were obtained by the refluxing of 2-(4-chloropyrimidin-5-yl)-5-((4-substituted ... Read More »

Various Synthesis Methods of 1,3,4-Oxadiazolederivatives: A Review

M Somashekhar*, R B Kotnal Department of Pharmaceutical Chemistry, Bldea’s College of Pharmacy, Vijaypur-586101. A B S T R A C T Heterocyclic molecules such as Oxadiazoles have been synthesized and evaluated for medical and agricultural activities. The disubstituted Oxadiazoles have executed a range of pharmacologic activities. 1,3,4-oxadiazole and 1,2,4-oxadiazole are better known, and more widely studied by researchers Among ... Read More »

Synthesis, Characterisation and Biological Evaluation of Novel Di substituted Quinazoline Linked with Cis Substituted Thio morpholine and 1, 2, 4 Triazole Moieties

V. Prabhakar*1, K. Sudhakar Babu1, L.K. Ravindranath1, J. Latha2 1Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, Andhra Pradesh, India. 2Department of Bio-technology, Sri Krishnadevaraya University College of Engineering & Technology, S.K. University, Anantapuramu–515003, Andhra Pradesh, India. A B S T R A C T A series of Quinazoline derivatives11 (a-f) were prepared by Nucleophilic substitution reaction of 2,4 di chloro ... Read More »

Comparative study on the phytochemical and free radical scavenging (antioxidant) activity of ethanolic extracts from different parts of Annona squamosa L. (Annonaceae).

C. Chandrashekar, V.R. Kulkarni* Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka. India. A B S T R A C T The present study aimed at the evaluation of preliminary Phytochemical and free radical scavenging (Antioxidant) potential of extracts of different parts of Annona squamosa L. plant and their correlation with the total phenolic contents (TPCs). The ... Read More »

Synthesis of s-Triazine substituted analogues of 1,5-benzodiazepines of medicinal interest

Vandana Singh*, Aditi Anand and D. Kishore  Department of Chemistry, Banasthali University, Banasthali-304022 (Rajasthan), India Abstract Synthesis of a series of 1,5-benzodiazepines substituted on its 3 and 4 positions with 2’-(amino /ethylamino/ piperidino-(4,6-biscyclopropylamino)) -1,3,5-triazines 12,10,7 and 14 respectively, from 2-methyl-1,5-benzodiazepin-4-one (4) has been described. Keywords: 1,5-Benzodiazepine, 2,4,6-trichloro-1,3,5-triazine.   Read More »

Synthesis and Antimicrobial Activity Evaluation of Poly ethylen imine (PEI) Dendrimer modified with 1,2,4-oxadiazole derivatives

Author Details Maziar Mansouji Avval1*, V. Srinivasa Murthy 2, S.Shashikanth1 1Department of Studies in Chemistry, University of Mysore, Manasagangorti 570006, India. 2BNM Institute of technology, Bhanashankari, Bangalore, 560 076, India. Abstract Dendrimers have wide range of applications in industry, Pharmaceutical and medicine. Oxadiazole compounds also have many applications in Pharmaceutical and medicine. Modification of dendrimers which have many branches like ... Read More »

Spectrophotometric Determination of Trace Lead in Biological Samples by using 2,4-di Methoxy benzaldehyde isonicotinoyl Hydrazone (DMBIH)

Author Details Ramakrishna Reddy. K*, Devanna. N, Chandrasekhar. K.B Department of Chemistry, JNTUA, College of Engineering, Anantapur, A.P, India. Abstract A rapid, simple, sensitive and selective spectrophotometric method has been developed for the determination of Lead (II) using newly synthesized Chromogenic reagent 2, 4-Dimethoxy benzaldehyde isonicotinoyl hydrazone (DMBIH). Lead (II) forms bright yellow coloured water soluble complex with DMBIH in ... Read More »

The Sources of Natural Antioxidants

About author Abhilash A*, Prabhu Raj KJ, Hemalatha M, Gopi Krishna B, Dr. Hindustan Abdul Ahad B. Pharmacy, Balaji College of Pharmacy, Anantapur, AP, India. * E-mail: [email protected] Abstract Intensive oxidative processes occurring in human organism lead to formation ofoxygen reactive forms, which can damage systemic cells and tissues. It is shown, thatbody endogenous protective system can be supported in ... Read More »


About author: P. Deepthi Dept. of Pharmaceutical Chemistry JNTUA – OTRI, Anantapur,India E-mail: [email protected] INTRODUCTION :A natural product is a chemical compound  or substance produced by a living organism – found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery, drug design. A natural product can be considered as such even if it ... Read More »

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