Synthesis, Characterisation and Biological Evaluation of Novel Di substituted Quinazoline Linked with Cis Substituted Thio morpholine and 1, 2, 4 Triazole Moieties

V. Prabhakar*¹, K. Sudhakar Babu¹, L.K. Ravindranath¹, J. Latha^2
1Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, Andhra Pradesh, India.
²Department of Bio-technology, Sri Krishnadevaraya University College of Engineering & Technology, S.K. University, Anantapuramu–515003, Andhra Pradesh, India.

A B S T R A C T
A series of Quinazoline derivatives11 (a-f) were prepared by Nucleophilic substitution reaction of 2,4 di chloro Quinazoline (4)  with hydrazine hydrate. The Structures of the Compounds are confirmed by IR, ¹H NMR &¹³C NMR Spectral data, Elemental Analysis, Mass spectral data. The compounds are also evaluated for their anti microbial and antifungal activity by Disc Diffusion Method, among them 11d & 11c are found as potent activity.  
Keywords: Quinazoline, synthesis, Antimicrobial & Anti Fungal Activity, 1,2,4 Tri Azoles, Thio morpholine