Friday , 1 November 2024

Synthesis of the new carboxylic α,α-diamino ester: Methyl 2-benzamido-2-(N-benzyl N-methylamino)acetate

El Houssine Mabrouk and Abdelilah El Hallaoui
Laboratory of Organic Chemistry, Faculty of  Sciences Dhar El  Mahraz, University  Sidi  Mohamed Ben  Abdellah,  B.P. 1796,  Fez,  Morocco

 A B S T R A C T
The title compound, Methyl 2-benzamido-2-(N-benzyl N-methylamino) acetate was synthesized in high yield by N-alkylation reaction between methyl α-bromo glycinate or methyl α-azido glycinate N-benzoylated and N-benzyl-N-methylamine in different solvents in the presence of various bases. The structure of this product was established on the basis of NMR spectroscopy (1H, 13C), and MS data.

Keywords: Amine, N-alkylation, α-Amino acids, Methyl α-azido glycinate, methyl α-bromo glycinate.

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