Monday , 18 January 2021

Synthesis of diethyl (2-benzoylamino-2-(2-hydroxyethoxy) methyl) phosphonate

El Houssine Mabrouk1*, Khalid Boukallaba1 and Abdelilah El Hallaoui1
1Laboratory of Organic Chemistry, Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, Fez, B.P.:1796-Fès Atlas, Morocco

The title compound, diethyl (2-benzoylamino-2-(2-hydroxyethoxy) methyl) phosphonate was synthesized in high yield by O-alkylation reaction between diethyl (2-azido-2-benzoylaminomethyl) phosphonate and ethane-1,2-diol in different solvents in the presence of various bases. The structure of this product was established on the basis of NMR spectroscopy (1H, 13C), and MS data.
Keywords: α-amino ester, O-alkylation, ethane-1,2-diol, diethyl (2-azido-2-benzoylaminomethyl) phosphonate, α-amino acids.

Scroll To Top