Synthesis and Characterization of 6-Phenylimidazo [1, 2-A] Pyridin-2-yl)-1H-Pyrazoamine Derivatives

Denish C. Karia^*1, Nilay Shah^2
1Assistant Professor Patel J. D. K. Science College Borsad-388540 Gujarat India
 ²Senior Executive, Cadila Health care Pvt. Ltd, Changodar-382219, Gujarat, India

A B S T R A C T
2-amino-5-bromo pyridine was treated with ethyl bromopyruvate followed by Suzuki coupling, acetonitrile-n-Buli reaction and cyclized with hydrazine hydrate at 80°C to get 6-phenylimidazo[1,2-a]pyridin-2-yl)-1H-pyrazoamine (5). This key intermediate was treated with acid chloride, aldehyde and methane sulphonyl chloride to yield desired compounds 6a-c, 7a-c and 8 respectively. 
Keywords: 6-phenylimidazo [1,2-a]pyridin-2-yl)-1H-pyrazoamine