Synthesis and Antifungal Properties of Some Nitroimidazole Derivatives

Justyna Żwawiak^1*, Waldemar Perdoch², Bartłomiej Mazela², Lucjusz Zaprutko^1 
1Dept. of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland
²Institute of Chemical Wood Technology, Poznan University of Life Sciences, Wojska Polskiego 28, 60-637, Poznań, Poland
Received: 21 June 2014, Accepted: 21 July 2014, Published Online: 10 August 2014

Abstract
A series of new nitroimidazole derivatives were synthesized and evaluated as antifungal agents. It was found that some of these products were moderate to good protectors against tested fungi species. The best fungal inhibition was observed for compound having methyl benzoate moiety and 2-methyl group in the imidazole ring. Moreover, some attempts of correlation of biological activity with clogP and PSA values of obtained products were performed.
Keywords: nitroimidazoles, p-hydroxybenzoates, nucleophilic substitution, ring opening reaction, antifungal activity