Thursday , 30 November 2023

Novel Specctrophotometric Methods for the Determination of Galantamine Hydrobromide in Bulk and Pharmaceutical Formulations by Cobalt Thiocyanate and Tpooo

K. Raghu Babu, S. Hemambika*
Department of Engineering chemistry, AU College of Engineering, Andhra University, Visakhapatnam, A.P, India.

Two simple and sensitive visible spectrophotometric methods M1 and M2 are described for the assay of galantamine hydrobromide in pure and solid dosage forms.  The method M1 is based on the formation of coordination complex between drug (electron donor) and CTC, colored species is formed and exhibits absorption maxima at 610nm. The method M2 is based on ion association complex formation of Tpooo with drug and exhibits absorption maxima at 500nm.  Regression analysis of Beer’s-lambert plots showed good correlation in the concentration ranges(0.5-3.0ml, 100µg/ml) for the method M1,(1.0-5.0Ml,500µg/mL) for the method M2 respectively.  The proposed methods are applied to commercial available tablets and the results are statically compared with these obtained by the UV reference method and validated by recovery studies.  The results are found satisfactory and reproducible.  These methods are applied successfully for the estimation of the galantamine hydrobromide in the presence of other ingredients that are usually present in dosage forms.  These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.
Keywords: Galantamine hydrobromide, Assay, Beer’s law, Cobalt thiocyanate, Tpooo, Regression equation.

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