Wednesday , 27 October 2021

Nanosuspension: Way to Enhance the Bioavailibility of Poorly Soluble Drug

Vijay Kumar Singh*, Dinesh Chandra, Preeti Singh, Shaunmdarya kumar, Ambikeshwar Pratap Singh,
Department of Pharmaceutics,
Kamla Nehru Institute of Management and Technology, Faridipur, Sultanpur, India

Nano suspensions are promising candidates that can be used for enhancing the dissolution of poorly water soluble drugs. Nan suspension is emerging as a preferred approach to address challenges involved in the delivery of BCS class-II compounds (poorly soluble and highly permeable). The development of nanoparticle formulations for BCS class-II drugs such as Itraconazole, Fenofibrate, Candesartan cilexetil would result in enhanced bioavailability, reduced systemic variability and more convenient dosing regimen. Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. The review article includes the methods of preparation with their advantages and disadvantages, characterization and evaluation parameters and pharmaceutical applications. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy to enhance dissolution rate.
Key words: Bioavailability & solubility enhancement, nanotechnology

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