Friday , 2 December 2022

Metal Complexes of (E)-N-(2-ethoxyphenyl)-2-(mercapto-phenylamino-methylene)-3-oxo-butanamide (EPMPB): Preparation, Characterization and Biological Activity

Ahmed. A. Gahlan*
Chemistry Department, Faculty of Science, Al-Azhar University, Assiut branch, 71524, Assiut, Egypt

Some novel transition metal [V(V), Co(II), Ni(II), Cu(II) and Cd(II)] complexes of (EPMPB) have been synthesized and characterized. Complexes were isolated in solid state and characterized by elemental analyses, electronic spectra, thermal method (TGA and DTA), IR and X-ray powder diffraction. The elemental analysis confirms the assigned stoichiometries. The present paper describes synthesis and characterization of these complexes. The complexes are found to have striking structural features. Metal: Ligand ratio is found to be 1:1 for all metal complexes. Hence V(V), Co(II), Cu(II) and Cd(II) complexes are octahedral and Ni (II) complex is  tetrahedral in geometry. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria S. marcescens (-ve), P. eruginosa (-ve), E. coli (-ve), S. aurous (+ve), B. cereus (+ve) and M. luteus and also the fungi C. albicans (-ve), G. Candidum (-ve), A. flavus (+ve), F.oxysporium (-ve), S. brevicaulis (+ve) and T.rubrum and results have been compared with the standard drug. .
Keywords: Transition Metals, EPMPB, Preparation, Characterization and Antimicrobial Activities.

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