Formulation Development and Evaluation of Fast Dissolving Tablet of Olanzapine by using Superdisintegrants

Kumawat Nekiram*, Sharma Amit, Satraval P.C.
Department of Pharmaceutics, Mahatma Gandhi College of Pharmaceutical sciences, Jaipur, Rajasthan

A B S T R A C T
Recent developments in the fast dissolving drug delivery system with improved patients compliance and convenience. Fast disintegrating tablets are solid dosage form which dissolves rapidly in saliva without chewing and additional water. Olanazapine is preferentially used for treatment of psychosis patients. The tablet of olanazapine was prepared by direct compression method using Cross-carmelose sodium, polyplasdone XL -10 ,sodium starch glycolate as super disintegrant and mannitol ,microcrystalline cellulose as diluents and Talcum ,magnesium stearate as lubricating agents. FT-IR study showed compatibility between drug and excipients. The pre-compression study indicated the excellent flow properties of bulk powder which is within an acceptable range of According to pharmacopeia specifications. The post-compression evaluation parameters results match the expected criteria specifications. These tablets have hardness 2.10 kg/cm², thickness 2.81mm, disintegration time of 28 seconds   and 96.65% drug release within 40 minutes.
Keywords: Olanzapine, cross Carmellose sodium, polyplasdone XL -10, sodium starch glycolate, Microcrystalline cellulose, mannitol, magnesium stearate.