P. Naresh Babu1 SK. Karimulla1, Anupam Kanti Bag1, M.Gobinath2, B. Bharathi*1
1Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore, A.P, India.
2Principal and Professor, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore, A.P, India.
A B S T R A C T
The anti-hyperlipidemic effect of ethanolic extract of heart wood of caesalpinia sappan L (CSP) was tested in Triton X 100 and High fat diet induced hyperlipidemic rat models. Here, Acute hyperlipidemia was induced by administration of single dose of Triton X 100 (100 mg/kg,i.p) and Chronic hyperlipidemia was induced by feeding fat diet for 21 days to rats. Treatment with CSP (200 and 400 mg/kg, p.o ) significantly reduced the hyperlipidemia i.e., decreased levels of serum total Cholesterol, triglycerides, low density lipoprotein Cholesterol (LDL C), very low density lipoprotein Cholesterol (VLDL-C) , and increase of serum high density lipoprotein Cholesterol (HDL-C) when compared to vehicle control and hyperlipidemic (diseased) groups. The results demonstrated that ethanolic extract of heart wood of caesalpinia sappan L possessed significant antihyperlipidemic activity.
Keywords: Triton, fat diet, hyperlipidemia, caesalpinia sappan L, heartwood, rats, Atrovastatin.