Thursday , 11 July 2024

Drug utilization studies in metabolic disorder

G. Kiran*, K.L Mary 1, V. Anusha2, Ajay CH3, Murali Krishna M4, Kiran Teja B5, K. Baby Siva Kumari6, K. Sharvani7
*134567A M Reddy Memorial College of Pharmacy, Narasaraopet, 522412, A.P, India
2SIMS college of Pharmacy, Guntur, A.P, India

A B S T R A C T
Hibiscus cannabinus (Kenaf) is a potential source of bioactive constituents and natural antioxidant. The current study determined the impact of various solvents on extraction yield, recovery of polyphenol and flavonoid, antioxidant, anticancer, and antibacterial properties of Kenaf leaves and seed. The powder of leaves and seed was separately extracted with n-hexane, ethyl acetate, ethanol, and water solvent. Among them, the ethanol extract of leaves and seed showed the highest extraction yield, and their GC-MS analysis revealed a total of 55 and 14 bioactive compounds, respectively. The total polyphenols (TP) and flavonoids (TF) content were quantified by a spectrophotometric technique where water extracts displayed a noteworthy amount of TP and TF content compared to other extracts. A similar demonstration was noticed in antioxidant activity, evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydrogen peroxide scavenging capacity. In addition, cytotoxicity and anti-lung cancer activity were identified against mouse embryonic fibroblast (NIH3T3) and human lung cancer (A549) cells.
Keywords: Hibiscus cannabinus, polyphenol, flavonoid, anti-lung cancer activity

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