Development of Enhanced Site Specific Periodontal Drug Delivery Systems for Minocycline HCl and Ciprofloxacin Films

Mukamalla Suresh*, Rohit Saraswat
School of Pharmacy, OPJS University, Churu, Rajasthan

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Ciprofloxacin hydrochloride, fluoroquinone antibiotic and Minocycline hydrochloride, tetracycline antibiotic that could be used in the treatment of periodontitis for localized therapy. The ciprofloxacin film was formulated using biodegradable polymer, gelatin and sodium alginate with poly ethylene glycol (PEG) 400. The film was evaluated for physicochemical properties such as thickness of the film, folding endurance, texture analysis, tensile strength, drug(s) content; in vitro drug(s) release studies, stability studies, in vitro antibacterial activity and bio-degradability study. The film displayed dose dependent antibacterial activity and was found to be stable. The approach provides an opportunity and potential for development of periodontal film containing both Ciprofloxacin and minocycline HCl for extended release.
Keywords: Films, Ciprofloxacin, Minocycline, Gelatin, Periodontal diseases.