Design and Novel Approaches of Orally Disintegrating Tablets

Author Details
S.S Siddheshwar*¹, R.K. Godge ², M.H.Kolhe¹, S.D.Mankar^1
1Department of Pharmaceutics, P.R.E.S.’s, Pravara Rural College of Pharmacy, Loni, India
²Department of Pharmaceutical Chemistry, P.R.E.S.’s, Pravara Rural College of Pharmacy, Loni, India

Abstract
Tablets designed to dissolve on the buccal (cheek) mucous membrane were a precursor to the ODT. This dosage form was intended for drugs that yield low bioavailability through the digestive tract but are inconvenient to administer parenterally, such as steroids and narcotic analgesics. Absorption through the cheek allows the drug to bypass the digestive tract for rapid systemic distribution. Not all ODTs have buccal absorption and many have similar absorption and bioavailability to standard oral dosage forms with the primary route remaining GI absorption. However, a fast disintegration time and a small tablet weight can enhance absorption in the buccal area. The first ODTs disintegrated through effervescence rather than dissolution, and were designed to make taking vitamins more pleasant for children. This method was adapted to pharmaceutical use with the invention of microparticles containing a drug, which would be released upon effervescence of the tablet and swallowed by the patient.
Keywords: Tablets, Zydis ODT, Claritin