Antimony chloride immobilized on neutral alumina: an efficient catalyst for the solvent-free selective synthesis of 2-substituted benzoxazoles

K.P.V. Subba Rao, P. Thriveni*, M. Hari Krishna
Department of Chemistry, Vikrama Simhapuri University, Nellore-524001, A.P, India.

A B S T R A C T
Synthesis of 2-substituted benzoxazoles from 2-amino phenol and aromatic aldehydes in an excellent yield using SbCl₃–Al₂O₃ as catalyst with microwave (MW) irradiation under solvent-free conditions. The present methodology shows some advantages such as short reaction times and enhanced selectivity under solvent-free conditions.
Keywords: Benzoxazoles, microwave, Lewis acid, selectivity