Department of Pharmacology, PES University, 100 Feet Ring Road, Banashankari, Bengaluru, Karnataka-560085.
A B S T R A C T
Naringi crenulata (NC) leaves have demonstrated different properties of nervous system. However, the leaves have not still studied to treat epilepsy. The aim of the present study was to determine the effect of NC hydroalcoholic extract on MES induced epilepsy in rats. Maximal Electroshock (MES) produces generalized electrical stimulation of the large portions of the brain; it provokes the neurons to fire repetitively, which is the characteristic of epileptic neurons. 30 female Wistar rats were divided into 5 groups. Group I was treated with water (2ml/kg), Group II with water (2ml/kg), Group III with phenytoin and diazepam, Group IV and V NC (200 and 400mg/kg) for 14 days. On 15th day MES (150mA for 0.2sec). The present research demonstrated that NC extract possesses a potential effect to prevent MES induced seizures in addition to increase GABA levels.
Keywords: Epilepsy, Naringi crenulata, Maximal electroshock (MES), seizures