A. Bhavana*, J. Nagalaxmi, M. Prasanna Teja, M. Venkateswarao, Ch. V. Suresh
Mother Teresa Pharmacy College, Sathupally, Khammam, Telangana-507303
A B S T R A C T
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Pongamia pinnata Linn. Pierre commonly known as ‘Karanj’ belonging to Fabaceae has been used in different system of traditional medicines for the treatment of various diseases. Pongamia pinnata leaves were collected and extraction was done by maceration process using ethanol as a solvent. Phytochemical investigation of extract was done and phytochemical tests for confirmation of the presence of alkaloids, tannins, flavonoids, steroids, glycosides, carbohydrates, aminoacids, proteins, fats & oils. In-vitro Antioxidant activity of the ethanolic extract of Pongamia pinnata was determined by hydrogen peroxide scavenging method. Pongamia pinnata had provided useful information for its identification. Leaves have alkaloids, flavonoids, tannins and saponins which have therapeutic value. Hydrogen peroxide is very important because of its ability to penetrate biological membranes. Hydrogen peroxide itself is not very reactive, but it can sometimes be toxic to the cell because it may give rise to hydroxyl radicals in the cells. Thus removing hydrogen peroxide is very important for the protection of living systems. Therefore the results indicate that Pongamia pinnata had strong hydrogen peroxide scavenging activity in dose dependent manner. Among all the concentrations 60μg/ml had shown the maximum activity.
Keywords: Pongamia pinnata, Phytochemical investigation, Hydrogen peroxide, Antioxidant activity.