A Novel HPLC Method for Quantitative Estimation of Nimodipine in Bulk and Pharmaceutical Dosage Forms

Askani Krishna Kumari¹, D. Swamy Charan², ³Gampa Vijay Kumar^3
1,2,3 KGR Institute of Technology and Management, Rampally, Kesara, Medchal Dist-501301, Telangana, India.

A B S T R A C T
Peptic ulcer disease is a serious gastrointestinal disorder that requires well targeted therapeutic strategy. Several drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapse, side effects and drug interactions. This has been rational for the development of new anti-ulcer drugs and search for novel molecules has been extended to herbal that offer better protection and relapse. The present study is to evaluate the anti-ulcer activity by using herbal remedy Centella asiatica. The ethanolic extract of Centella asiatica treated groups shows a significant effect when compared to control group animals which indicating that the plant having the anti-ulcer activity. And, the results showed that the ethanolic extract of the Centella asiatica having the antioxidant activity. The acute toxicity study conducted for ethanolic extract of Centella asiatica indicates that safe up to 2000mg/kg body weight.
Keywords: Centella asiatica, Anti-Ulcer, Ethanolic etc.