Wednesday , 20 March 2019

Tag Archives: Sofosbuvir

Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Ledipasvir and Sofosbuvir in Bulk and Pharmaceutical Dosage Form

D. Hemalatha, G. Dharmamoorthy* Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati-517506, A.P, India ABSTRACT A simple, Accurate, precise method was developed for the simultaneous estimation of the Ledipasvir and Sofosbuvir in bulk and its  Tablet dosage form. Chromatogram was run through Std Kromosil C18 (150 x 4.6 mm, 5m) column. Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken ... Read More »

Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Ledipasvir and Sofosbuvir in Bulk and Pharmaceutical Dosage Form

D. Hemalatha, G. Dharmamoorthy* Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati-517506, A.P, India ABSTRACT A simple, Accurate, precise method was developed for the simultaneous estimation of the Ledipasvir and Sofosbuvir in bulk and its  Tablet dosage form. Chromatogram was run through Std Kromosil C18 (150 x 4.6 mm, 5m) column. Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken ... Read More »

Stability Indicating RP-HPLC Method for Simultaneous Estimation of Sofosbuvir and Velpatasvir in Bulk and Pharmaceutical Dosage Form

V. Hari Baskar, Ramesh Dhani*, P. Priyanka, M. Suchitra Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Nellore. ABSTRACT A simple, precise, accurate rp-hplc method has been developed and validated for the sofosbuvir and velpatasvir in bulk and pharmaceutical dosage form. This method was carried out by using Inertsil ODS-3(4.6 x 150mm, 5mm).  Mobile phase containing phosphate buffer (ph4.8): ... Read More »

Method Development and Validation of Sofosbuvir and Ledipasvir in API & Its Pharmaceutical dosage forms by RP-HPLC

Shinnde Sandeep* Department of Pharmaceutical Analysis & Quality Assurance ,SSJ College of Pharmacy,Vattinagulapally, Gandipet, Hyderabad – 500075, Telangana State A B S T R A C T Ledipasvir is indicated in patients with hepatitis C virus (HCV) genotype 1 for treatment of chronic hepatitis as a combination therapy, which includes peg interferonalfa and ribavirin. Ledipasvir is a protease inhibitor for ... Read More »

Method Development and Validation for Simultaneous Estimation of Velpatasvir and Sofosbuvir by Using RP-HPLC in Bulk and Pharmaceutical Dosage Form

Durbhakula Pradhathri*, P. Sirisha, AVSS. Gupta, A. Mohan Goud, P. Nagaraju, M. Shyamala, J. V. C. Sharma, G. Srimounika, B. Anusha Reddy, V. Revathi Department of Pharmaceutical Analysis & Quality Assurance, Joginpally BR Pharmacy College, Moinabad, Rangareddy, Hyderabad, Telangana. ABSTRACT A New method was established for simultaneous estimation of Velpatasvir And Sofosbuvir by RP-HPLC method.   Chromatographic separations were carried using YMC (4.6 ... Read More »

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