Wednesday , 17 July 2019

Synthesis of the new carboxylic α,α-diamino acid: Benzoylamino-(2-methyl-quinolin-4-ylamino) acetic acid

El Houssine Mabrouk*
Laboratory of Organic Chemistry, Faculty of  Sciences Dhar El  Mahraz, University  Sidi  Mohamed Ben  Abdellah,  B.P. 1796,  Fez,  Morocco

A B S T R A C T
After the obtaining of the N-protected methyl α,α-diamino ester via N-alkylation reaction between methyl α-bromo glycinate N-benzoylated and 2-methyl quinolin-4-amine, the synthesis of benzoylamino-(2-methyl-quinolin-4-ylamino) acetic acid in high yield through alkaline hydrolysis reaction of methyl 2-benzamido-2-(2-methylquinolin-4-ylamino) acetate was performed via cleavage of the protecting group. The structure of these products were established on the basis of NMR spectroscopy (1H, 13C), and MS data.
Keywords: N-alkylation, α,α-Diamino ester, α,α-diamino acid, methyl α-bromo glycinate, alkaline hydrolysis reaction.

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