Tuesday , 22 September 2020

Synthesis, Characterization of Pyrimidine Derivatives and their Cytotoxic Activity

Ramisetty Anna Poornima*1, Dr. N. Srinivasarao
1Department of Pharmaceutical Chemistry, Vikas College of Pharmacy, Visannapeta, Krishna-521215(Dt), A.P, India
2Professor & Principal, Department of Pharmaceutical Analysis & Qualitative Assurance, Vikas College of Pharmacy, Visannapeta, Krishna-521215(Dt), A.P, India

A B S T R A C T
Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by 13C, 1H NMR spectral data. Some of the new compounds were pMDAMB (breast cancer) using MTT assays. The pyrimidine derivatives 11a, 11b, 11c and 11e serve as good leads for further studies to develop potent cytotoxic agents.
Keywords: Pyrimidine derivatives, cytotoxic activity, MTT assay

Scroll To Top