Sunday , 30 April 2017

Synthesis, characterization and Biological Evaluation of 3,4-bis(substituted-Phenyl)-7-(2,6- dichloro-4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-C:5,4- C’] diisoxazoles from 2, 6- dichloro-4-trifluoro methyl aniline

Shankarsing Sardarsing Rajput*1, Rahebar Ali Mohammed Ali Sayyed2
1Department of Chemistry, SVS’s Dadasaheb Rawal College Dondaicha, Dist.Dhule, (M.S) 425408, India
2Department of Chemistry, PSGVPM’s Arts, Commerce and Science College, Shahada, Dist. Nandurbar (M.S) 425409, India

A B S T R A C T
The five membered cyclic imide derivative of 2, 6 dichloro-4-trifluoromethyl aniline was synthesized by reacting succinic anhydride with 2, 6 dichloro-4-trifluoro methyl aniline in presence of acetyl chloride and benzene. The resulting imide derivative was condensed with substituted aromatic aldehydes in presence of acetic acid gives bis-heterocyclic chalcones. These chalcones underwent ring closure with hydroxylamine hydrochloride afforded bis-isoxazole derivatives of 2, 6 dichloro-4-trifluoromethyl aniline. The synthesized compounds were screened for their spectral analysis and biological evaluation.

Keywords: Cyclic imides, chalcone, isoxazole

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