Friday , 23 August 2019

Synthesis, Characterisation and Biological Evaluation of Benzo [1, 4] Diazepine Derivatives linked with 7-aza Indole ring

V. Prabhakar*1, C. Divya Vani2, B. Roopa2 
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India.
2Department of Chemistry, Sri Padmavati Women’s Degree & PG College, Tirupati, Andhra Pradesh, India.

Heterocyclic compounds occur widely in nature and quite a few of these are essential to life processes. The literature on heterocyclic compounds is replete with examples of a large number of synthetic methods of naturally occurring systems which are pharmacologically active. The heterocyclic compounds containing nitrogen has expanded exponentially in the past decades due to their unique physical properties, specific chemical reactivity and their remarkable potential biological activities. A survey of literature on the nitrogen heterocycles reveal that diazepines are important constituents of a wide variety of natural products with pharmacodynamic application. O-Phenylene di amines (OPDA) undergo smooth condensation reaction with α,β-unsaturated-7 Aza indole core unit structure   carbonyl compound derived from 1-methyl-1H-pyrrolo [2,3-b]pyridine-3-carbaldehyde in the presence of 5 mol% of  InCl3 under mild conditions to afford a new class of 1,5- benzodiazepine Derivatives  in good yields. All these compounds were screened in vivo, for their anti-inflammatory activity. Compound 10a was found to be most potent compound of this series and was compared with the reference drug diclofenac. The structures of these compounds have been established by IR, 1H NMR and 13C NMR spectral data.
Keywords: Vic-Di amines, α, β-unsaturated- aldehyde, 7-Aza Indole ring, diazepines, Anti-Inflammatory Activity.

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