Monday , 3 August 2020

Isolation, Characterization, and Biological Activities of Gossweilerine, an Unusual Quaternary Alkaloid from Drypetes Gossweileri

Joseph Ngoupayo1, Turibio K. Tabopda2*, Muhammad Shaiq Ali3, Marie-Aleth Lacaille-Dubois4
1Faculty of Medicine and Biomedical Sciences; BP 1364 Yaoundé, Cameroun
2Département de Chimie Organique, Université de Yaoundé I ; BP 812 Yaoundé, Cameroon,
3H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan and
4Laboratoire de Pharmacognosie, UMIB UPRES EA 3660, Faculté de Pharmacie, Université  de Bourgogne, Dijon, France

A B S T R A C T

A new quaternary alkaloid, gossweilerine, together with four known compounds was isolated from the barks of Drypetes gossweileri. The structures of the new and known compounds were established on the basis of one- and two-dimensional NMR and HR-EI-MS data as gossweilerine (1), gossweilone (2), friedelin, 3,7-dioxofriedelan, and 3-oxo-16β-hydroxypachysonol. Gossweilerine (1) and gossweilone (2) displayed a cytotoxic activity on brine shrimp (Artemia saline), with a LD50 7.12 and 19.31 µg/mL, respectively and in-vitro phytotoxicity with growth regulation of 14.6 and 54.9% respectively at concentration of 10µg/mL. These compounds were also evaluated for antibacterial and antifungal activities. Compound 1 exhibits significant activities against E. coli, S. aureus, S. typhii, T. longiformis, and M. canis while compound 2 exhibits significant activities against E. coli and S. typhii, and weak to moderate inhibitory activities against all fungi.
Keywords: Drypetes gossweileri; Euphorbiaceae; Alkaloid; Antimicrobial; cytotoxicity; Phytotoxicity

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