Y. Krishna Reddy*, S. Rakesh, S. Roja, S. Mounika, S. Bhargavi, Sd. Umma Salma
Bomma Institute of Pharmacy, Khammam, Telangana, India
A B S T R A C T
The present dissertation work is an attempt to select the best possible diluent- disintegrant combination to formulate rapidly disintegrating tablets of Flunarizine, which disintegrates in matter of seconds in the oral cavity, thereby reducing the first-pass metabolism and the time of onset of pharmacological action. Crospovidone, Croscarmellose sodium and Sodium starch glycolate were used as super-disintegrants. Avicel was used as diluent. Aspartame was used as a sweetening agent. Magnesium stearate and Aerosil were used as lubricant and glidant respectively. Aqueous Wet-granulation method was employed to formulate the tablets, because direct compression showed tablet defects like capping and poor flow of powder blend. The precompression parameters like bulk density, tapped density, Carr’s index and angle of repose were determined. All the 9 formulations showed acceptable flow properties. The postcompression parameters of the tablet like the hardness, thickness, friability and weight variation, disintegration time, wetting time, and Invitro release were carried out and the values were found to be within IP limits. The percentage drug content of all the tablets was found to be between 92.55 % and 99.34 % of Flunarizine, which was within the acceptable limits. From the data obtained, it is observed that amongst the various combinations of diluents and disintegrants used in the study, tablets that were formulated (wet granulation) using Crospovidone (3.33%), Croscarmellose sodium and sodium starch glycolate (each 0.83%) exhibited quicker disintegration of tablets than compared to those other combination of disintegrants in different concentration. The effectiveness of super-disintegrants was in order of CP>CCS>SSG.
Keywords: Flunarizine, Croscarmellose sodium, sodium starch glycolate, Carr’s index