Wednesday , 20 September 2017

Formulation and Evaluation of Fast Dissolving Oral Films of Lansoprazole

Polisetty Chandana*, Venkata Ramana Bachu, Venkata Badarinath Atluri
Dr. K. V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India – 518218

Catharanthus roseus was found to posses different medicinal properties like wound healing, antioxidant, antimicrobial, anthelmintic, anti-ulcer, antilipidimic, anti-cancer, anti-fungal, anti-diabetic, sedative tranquilizer, hypotensive and memory enhancing  properties. The present work was aimed to formulate herbal ointments using different types of ointment bases available i.e., Oleaginous bases, Absorption bases and Emulsion bases by incorporating the aqueous extract of Catharnthus roseus and to evaluate the prepared ointments for the desired parameters. Ointments were prepared using fusion method and emulsification method. The prepared ointments were evaluated for the parameters like Colour, odour, consistency, loss on drying, pH, spreadability, viscosity, diffusion study, Phase separation study and stability studies. The physical parameters of all formulated ointments shown acceptable results and the ointments prepared using Emulsion bases shown quite acceptable results than other ointments. The physical parameters were within the acceptable range after stability studies of one month at different temperature conditions i.e., 4˚C, Room temperature and 40˚C and the formulations were found to be stable at the end of stability studies. Based on the results we conclude our work that the ointments prepared using emulsion ointment bases was found to have quite acceptable properties than the other types of ointment bases.

Keywords: Herbal ointment, ointment base, emulsion base, stability

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