HOD, Pharmaceutical Analysis and QA, Gyana Jyothi College of Pharmacy, Boduppal, Hyderabad.
A B S T R A C T
The objective of this study was to develop effective mucoadhesive buccal tablets comprising of drug containing bioadhesive layer. Granisetron hydrochloride was formulated as buccal tablets to improve its bioavailability by avoiding first pass metabolism. HPMC K15M, HPMC K100M and CARBOPOL 934 were selected as polymers various formulations were prepared by using these polymers. Ex-vivo permeation study of Granisetron hydrochloride drug solution through the Porcine buccal mucosa was performed using Franz diffusion cell and the flux value was found to be 424.735 µg hr-1cm-2. The pre-compression blend of Granisetron hydrochloride Buccal tablets were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio and all the results indicated that the blend was having good flow nature and better compression properties. The swelling studies were performed for the formulations which were shown desired drug release. The formulations prepared with Carbopal 934 in the concentration of 20mg (F8) were showing better result 92.09% drug release. The selected formulations F8 formulation was showing maximum flux value and permeability coefficient value i.e., 389.42 (µg hrs-1cm-2) and 0.111 (cm/h). From the release kinetics, data it was evident that the formulation was following zero order kinetics with regression value of 0.986 and it is following non-fickian diffusion mechanism.
Keywords: Granisetron Hydrochloride, Buccal Tablets, Carbopol