Saturday , 22 September 2018

Formulation and Evaluation of Ondansetron Hydrochloride Bilalyered Buccal Tablets: I an In Vitro and Ex vivo

J. Bhaskar1*, T. Ramchandar2, V.L. Narasaiah3
1Dept. of Pharmaceutics, Princeton Institute of Pharmaceutical Sciences, Hyderabad, Telangana, India.
2Dept. of Pharmaceutics , Mother Teresa college of Pharmacy, Ghatkesar, Hyderabad, Telangana India.
3Dept. of Pharmaceutics, Dr Samuel George Institute of Pharmaceutical Sciences, Markapur, Prakasam, A.P, India.

A B S T R A C T
The aim of the present study was to develop and evaluate a buccal adhesive tablet containing ondansetron hydrochloride (OH). The tablets were prepared using carbopol (CP 934) and hydroxyl propyl methylcellulose (HPMC K15M) as mucoadhsive polymers to impart mucoadhesion and ethyl cellulose to act as an impermeable backing layer. The formulations were prepared by direct compression and characterized by different parameters such as weight uniformity, content uniformity, thickness, hardness, swelling index, in vitro drug release studies, mucoadhesive strength, and ex vivo permeation study. The result of the in vitro release studies and permeation studies through bovine buccal mucosa revealed that complexed Ondansetron gave the maximum release and permeation. Optimized formulation characterized by Fourier transform infrared study and it was found not having any interaction with polymer and drug.
Keywords: Buccal tablet, buccal delivery, mucoadhesion, Ondansetron hydrochloride, FTIR

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