B. Venkateswara Reddy1*, M.Sekar2
1Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal, Kurnool Dt-518501
2Department of Pharmaceutical Chemistry, Santhiram College of Pharmacy, Nandyal, Kurnool Dt-518501
A B S T R A C T
The aim of the present study was to design mucoadhesive tablets of Metoprolol Tartarate to release the drug unidirectionally in buccal cavity in order to avoid first-pass metabolism for improvement in bioavailability and to improve patient compliance. An attempt has been made to develop mucoadhesive tablets of Metoprolol Tartarate containing bioadhesive materials. Tablets were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, and sodium carboxy methylcellulose. The pre-formulation blend was subjected to micromeritic study and has shown good flow properties. The formulated tablets were evaluated for various quality control parameters and the results were within in the specified limits of pharmacopoeia. Release of Metoprolol Tartarate from the developed formulations has been studied over a period of 10 hours. Of all the formulations developed formulation F8 containing Drug and Carbopol 974 in 1:0.5 ratio have shown a desired increased drug release up to 10 hours with a maximum of 97.47%. Thus, formulation F8 is considered as the best one in comparison with other formulations. The drug release from the optimized formulation is by zero order kinetics and the mechanism of drug release is by diffusion. The optimized formulation is compared with the innovator product Beloc-Zok and the drug release was more in the optimized formulation than the innovator product.
Keywords: Mucoadhesive, Metoprolol Tartarate, First-pass metabolism, Bioadhesive polymers, Zero order kinetics.