D. Lakshmi1, K. Sunil kumar2
1Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhrapradesh, India.
2Associate Professor, Department of Pharmaceutics, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
The primary objective was to formulate & evaluate gastroretentive floating tablets of the Captopril by using different polymers in different ratios. Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), it isused in the treatment of hypertension. Twelve formulations of floting tablets were prepared by using direct compression method. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution. Out of all the formulation developed, Formulation 3 gave better-controlled drug release and floating properties in comparison to the other formulations. Hence, developed floating tablets of Captopril are formulated to increase gastric residence time and thereby improve its therapeutic efficacy.
Keywords: Captopril, Direct compression method, Polymers, Formulation, Floating tablet