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1U. Sambamoorthy*, 1D. Yashwant kumar, 2G. Venkata Ramana, 3K. Suresh, 4J. Sunil
1SARC – (Scientific and Applied Research Center) Hyderabad
2Balaji institute of Pharmaceutical sciences, Narsampet, Warangal, Telangana.
3Pratishta Institute of Pharmaceutical Sciences, Durajpally Suryapet, Telangana.
4Geetanjali college of Pharmacy, keesara, Hyderabad, Telangana.
Abstract
Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration. Telmisartan antagonizes the effect of angiotensin II (vasoconstriction and aldosterone secretion) by blocking the angiotensin II (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP. In the present investigation telmisartan floating tablets were prepared by using different grades of polymers such as HPMC K4M, PEO WSR 303, and XANTHUM GUM. Formulated tablets showed satisfactory results for various Post compression evaluation parameters like: tablet thickness, hardness, weight variation, floating lag time,total floating time, content uniformity and in vitro drug release.the Physical parameters & floating characterstics were not good with the PEO AND XANTHUM GUM as CR polymers. HPMC K4M at Drug: Polymer ratio of 1:1.5 respectively showed better Sustained drug release of model drug. Formulation F6 gave better-controlled drug release and floating properties in comparison to the other formulations. The release pattern of the F6 formulations was best fitted to Korsmeyer-Peppas model, Higuchi and ZERO-order model and the release pattern from the formulation was non-Fickian diffusion or anomalous diffusion.
Keywords: Telmisartan, HPMC K4M, floating drug delivery, non-Fickian diffusion
