M. Siddeswara*, M. Purushothaman, M. Pradeep Kumar, M. Santhosh Raja, S. Yasmin, R. Swathi
Department of Pharmaceutics, Vasavi Institute of Pharmaceutical Sciences, Kadapa, A.P, India
A B S T R A C T
Corn starch is abundantly available in nature with the help of it we can prepare controlled release dosage form. Starch hydrogel is the current area of research for developing various controlled release dosage forms. Starch hydrogels are prepared easily with the normally available ingredients. The major advantage of hydrogel is the control release behavior up to 24 hrs. In the present study corn starch hydrogel was prepared by using Glutaraldehyde reagent and Poly Vinyl Alcohol they formed hydrogel was able up to control the drug release up to 24 hrs. The swelling behavior and drug release studies were performed and the dissolution data was fit into various kinetic models which showed drug release mechanism was of non fickian diffusion type.
Keywords: corn starch, hydrogel, glutaraldehyde, Poly Vinyl Alcohol