N. P. Ndahi1, M.B. Fugu1, I. Waziri1 and Y. A. Geidam2
1Department of Chemistry, University of Maiduguri, Maiduguri, Borno State, Nigeria
2Department of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria
A B S T R A C T
Complexation plays a vital role in drug development as a means of modifying the pharmacological, toxicological and physico-chemical properties of drugs. In this study, Copper (II) and Silver (I) complexes of cefuroxime were synthesized by solvent free technique (mechanochemical). The complexes were characterized by physico-chemical methods such as infrared, UV/Visible, elemental analysis, melting point, solubility and conductivity. Based on the results obtained, the complexes were proposed to have the formula [Cu(CFU)2H2O] and [Ag(CFU)NO3] where CFU stand for cefuroxime. The antimicrobial activities of the synthesized complexes were tested using disc diffusion method, against different strains of bacteria such as Strepto coccus pneumonia, Bacillus subtillus, Salmonella typhi, Klebsiella pnuemoniae, Escherichia coli, Methicillin-resistance staphylococcus aureus (MRSA) ,Pseudomonas aeruginosa and Staphlylococcus aureus. It has been observed that the complexes have higher activity than the free ligand. The IR spectral data indicates that CFU coordinate to the metal ion through v(COO), v(C=O) and oxygen atom of water molecule. The melting point, colour and electronic spectra of the complexes were different from that of the ligand, which suggest formation of coordination compounds.
Keywords: Antibiotic resistance, Cephalosporin, Silver, Copper and Mechanochemical