Nancy Dixit*, Avinash Gupta, Rajesh Asija, Manish Sharma
Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India-302020.
The purpose of the present investigation was the formulation and characterization of lipospheres of pravastatin sodium for continuously release to improve bioavailability and to improve drug entrapment. There were various formulations of pravastatin sodium were prepared by melt dispersion technique using Poloxamer 118, Tween 80, Gelatin as surfeactent and they were evaluated for particle size, surface morphology, drug entrapment efficiency, flow properties, buoyancy percentage and In-vitro drug release and stability studies. The shape and surface morphology of prepared lipospheres were characterized by optical and scanning electron microscopy, respectively. The particle was found to be discrete and spherical and average particle size of formulations was found to be 45.6 µm. As the concentration of polymers increases, it affects the various evaluation parameters like particle size, in-vitro drug release. The lipospheres of optimized formulation exhibited the prolonged release of 97.1% in a constant way up to 4 hours. From this study it is concluded that the optimized formulation of pravastatin sodium lipospheres can be selected targeted drug delivery system for improved bioavailability and better drug entrapment.
Keywords: Lipospheres, Pravastatin Sodium, Poloxamer 11, Tween 80