Friday , 28 April 2017

Development and Evaluation of fast dissolving tablets of Fenofibrate by enhancing dissolution rate and bioavailability

Y. Krishna Reddy*, M. Vanaja, N. Akhila, N. Mamatha, M. Sruthi, P. Srilekha
Bomma Institute of Pharmacy, Khammam, Telangana, India

A B S T R A C T
In the present work, an attempt has been made to develop fast disintegrating tablets of Fenofibrate. In the present work Sodium starch glycolate, Cross povidone and Cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. Camphor was employed as sublimating agent, due to presence of camphor maximum pores will be formed. As the numbers of   pores were more the body fluid will penetrates more easily. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 98.10 % in 25 min hence it is considered as optimized formulation.
Keywords: Fenofibrate, Sublimating agent, camphor, sodium starch glycolate, Cross povidone and Cross carmellose sodium.

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