Nutan Kumari*, Renu Kalyanwat, Vikas Kumar Singh
SCHOOL OF PHARMACEUTICAL SCIENCES
JAIPUR NATIONAL UNIVERSITY, INDIA
Nasal route for the administration of drugs is used as an alternative route for the systemic availability of drugs restricted to intravenous administration. Intranasal Therapy has been an accepted form of treatment in the Ayurvedic system of Indian Medicine.The absorption of drug at the olfactory region of the nose provides a potential for a pharmaceutical compound to be available to the central nervous system. In this review we discuss the Advantages, Disadvantages, Limitation, Mechanism of nasal drug absorption biological, physicochemical and pharmaceutical Factors Affecting nasal absorption, Bio-availability Barriers, and Strategies to improve nasal absorption, New Developments in Nasal Dosage Form design, Evaluation of Nasal Formulations and Applications of nasal drug delivery system.
Key words: Nasal route, Intranasal drug delivery, Hepatic first pass metabolism.