Sunday , 30 April 2017

Antibacterial Activity of 2-(1H-benzo [D]imidazol-2-ylimino)-5-arylidenethiazolidin-4-ones, 1-(1H-benzo[d]imidazol-2-YL)-5-alkyl-3-aryl-1, 3,5-triazinane-2-thiones and 3-(1H-benzo[d]imidazol-2-yl)-5-aryl-1,3,5-oxadiazinane-4-Thiones

Karnaji Harkalaa, Laxminarayana Eppakayala*a, Ramesh Domalab and Thirumala Chary Maringantic*
aMahatma Gandhi Institute of Technology, Chaitanya Bharati, Gandipet, Hyderabad, Telangana-500075
bMahatma Gandhi University, Aneparti, Nalgonda, Telangana 508254
cJawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana -500 085

A B S T R A C T
The antibacterial activity of 2-(1H-benzo[d]imidazol-2-ylimino)-5-arylidenethiazolidin-4-ones, 1-(1H-benzo[d]imidazol-2-yl)-5-alkyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(1H-benzo[d]imidazol-2-yl)-5-aryl-1,3,5-oxadiazinane-4-thiones have been investigated against  staphylococcus, Aureus Klebsiella Pneumoniae Salmonella Paratyphi A Salmonella Paratyphi B Micrococcus Luteus. The compounds have inhibited the spore germination of three fungi even at low doses. The compounds with chloro substituted were found to exhibit very high activity against all the bacteria.

Keywords: Antibacterial activity, thiazolidin-4-one, oxadiazinane, triazinane-2-thione and benzo[d]imidazole

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