Saturday , 21 September 2019

Analytical method for the determination of Escitalopram and L-methyalfolate by RP-HPLC Method

1B.Poornima*, 2P. Jayachandra Reddy, 3D.S.S.N. Neelima
1HOD, Associate Professor, Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupathi
2Principal, Professor, Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh
3Scientific & Applied Research Center, Hyderabad, Telangana State.

A B S T R A C T
Analytical Chemistry seeks ever-improved means of measuring the chemical composition of natural and artificial materials. The techniques of this science are used to identify the substances, which may be present in a material, and to determine the exact amounts of the identified substances. Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements, which arise constantly in our society. They adapt proven methodologies to new kinds of materials or to answer new questions about their composition. Escitalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. L-methylfolate is the only metabolite of folate that can cross the blood-brain barrier, and it is this form that can directly impact several important CNS reactions, most notably the synthesis of three important neurotransmitters: serotonin, norepinephrine, and dopamine. Simultaneous estimation of Escitalopram and L-methylfolate in tablet dosage form by RP-HPLC Method. The method was validated as for ICH guidelines and it can be used for the routine analysis of Escitalopram and L-methylfolate in tablet dosage form.
Keywords: Escitalopram, methylfolate, estimation, RP-HPLC, method development

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