V. Saichitra Prathyusha*
Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore-524346
Riverblindness is also called onchocerciasis . It has historically been one of the leading causes of infectious blindness worldwide. It is endemic to tropical regions both in Africa and latin amercia and in the yemen . onchocerciasis is caused by infecrtion waith the filarial parasite onchocerca volvulus. The infection is spread through the bites of an insect vector, black flies of the genus simulium . in Africa , the major vectors are members of the sdamnosum complex, wahile numerous species serve as vectors of the parasite in latin amercia. It is a neglected tropical disease which is in disperate need of a therapeuhic revolution. Its pathology, whose saymptoms are anchodermatitis, musculoskeletal pain and various stages of blindness , is a result of the deataha of the microfilariae in the sakin and eyes , the emergence of ivermectin rasistance inastifices the crucial need to identify new drug targets and agents that can effectively treat onchocerciasis.
Keywords: Neglected tropical diseases, Onchocerciasis, onchocerca volvulus, Ivermectin, chitinaasae, scaffold hopping.