Tuesday , 27 June 2017

Adiposis Dolorosa – A Scientific Review

Ramesh Dhani, M. Gobinath, G. Divya*, Sonalika Patro, C. Yamini, T. Lavanya
Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore, Andrapradesh, India

ABSTRACT
Adiposis dolorosa was described by American neurologist francis Xavier dercum in 1892, adiposis dolorosa is a relatively unknown condition characterized by great and localized adiposity with pain, deposition of subcutaneous fatty tissue may occur in many parts of the body by applying pressure to the nerves and mental phenomena including emotional instability. Middle aged females are more affected in menopausal age. In some cases woman of 67-years old are prone to the dercum’s disease after the intake of tocilizumab, an anti interleukin-6 reported monoclonal antibody to treat rheumatoid arthritis. In some case report demonstrates successful symptomatic treatment of the patient by lidocaine of 5mg/kg body weight by the intravenous infusion to relief the pain lasting several weeks or even months. These fatty tissue deposits  had shown significant reduction of pain on surgical excision or liposuction. The upper arms, elbows, stomach wall, thigh, or knees are the   most commonly affected parts by dercum disease.
Key words: Dercum’s disease, adiposis dolorosa, obesity, chronic pain

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