Thursday , 23 March 2017

A Review on Solubility Enhancement Using Hydrotropy

Angilicam Avinash*, Avula Sushma, Koneti Lalasa, Siddabathina Prasanth Kumar, Thumati Gowthami, Dr. M. Sreenivasulu
Narayana Pharmacy College, Chinthareddypalem, Nellore, Andhra Pradesh, India-524003.

The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action. Therapeutic effectiveness of a drug basically depends upon bioavailability and the solubility of drug moiety. Most of the chemical entities that are being discovered are lipophilic and have poor aqueous solubility. A more than 40% drug suffers from poor water solubility. Solubility is one of the important parameter to achieve desired concentration of drug in systemic for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and reducing side effects for certain drugs. This is true for parentally, topically and orally administered solutions. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. and have many advantages like; it does not require chemical modification of hydrophobic drugs, use of organic solvents or preparation of emulsion system.
Keywords: Bioavailability, Drug efficacy, Hydrotropy, Lipophilic, Solubility enhancement.

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