Saturday , 22 September 2018

A Review of Anticoagulant Activity of a Fucoidan from Undaria Pinnatifida Sporophy ll

Chirumanu Ramadevi*, Kongi Kavya Sudha, Ballavolu Sandeep
Swathi College of Pharmacy, Venkatachalam, Nellore

Abstract
Undaria pinnatifida is brown sea weed. Fucoidan is a group of marine sulfated polysaccharides of the cell-wall matrix of brown algae, containing large proportion of L-fucose and sulfate, together with minor amounts of other sugar like xylose, galactose, glucose, mannose, uronic acid, and rhamnose. Fucoidan medically used as anti-inflammatory, antiviral, anticoagulant, antitumor and antiangiogenesis. Fucoidan  changes the  liquid form of blood into gel type leads to blood clotting. Blood coagulation involve complex interactions between plate lets , coagulation factors and injured vessel wall. Platelets are disc shape eliments   they aggregate or clump together during blood clotting. Many studies on this activity of fucoidan have proved effect on blood coagulation. It has been proposed as alternatives to the anticoagulant heparin.

Keywords: Undaria pinnatifida, Fucoidan, uronic acid, anticoagulant activity

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