Monday , 24 April 2017

A Prospective Study on Treatment Outcomes and Safety Parameters of Anti Tubercular Regimen in Tuberculosis

Kishore Sanam Jain, B. Kumar*, M. Gobinath
Department of Pharmacy Practice, Ratnam institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India

A B S T R A C T
Tuberculosis is highly prevalent in developing countries of Asia, Africa and South America, caused by tubercle bacillus. The mycobacterium agents also cause this infection like M. bovis, M. africanum, M. microti, M. caprae, M. pinnipedii, M. canetti and M. mungi. Clinical manifestations depends on few host related factors like age, malnutrition, Study was conducted in TB clinic, Dodla Subba Reddy Hospital, Nellore, Andhra Pradesh, India, visiting the TB clinic, were screened clinically and diagnostically for TB disease, The blood sample were collected before and after 4 weeks after initiation of therapy, Nephrotoxicity can be assessed by the measurement of serum creatinine levels before and after 4 weeks of the initiation of the therapy and difference of the mean values of creatinine before initiation and after 4 weeks of initiation of therapy is determined. Mean values of creatinine before and after the therapy was found to be as 0.9 and 1.2 which was found to match with the study conducted by Sandor Klis on streptomycin in treating other disease condition which showed the development of nephrotoxicity within 4 weeks of the treatment of 9% in 41 patients. Our study also evaluated hematological toxicities which evaluated parameters of hemoglobin, Neutrophils and ESR and these depicted the development of anemia and the mean values was found to be of 9 gm%.
Keywords: Tuberculosis, Nephrotoxicity, ESR, anemia.

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