Tuesday , 13 April 2021

Synthesis, Characterisation and Antimicrobial Activity of 1-(Morpholin-4-yl)-2-(1,3,4-Oxadiazol-2 Ylsulfanyl)Ethanone Derivatives

M Somashekhar1*, R B Kotnal1, N V Kalyane1
1Department of Pharmaceutical Chemistry, BLDEA’S College of Pharmacy, Vijaypur-586101.

A B S T R A C T
Considering the biological and chemical relevance of Morpholine derivatives, we have devised novel derivatives of morpholine. The series of morpholine derivatives were synthesized in high yield and quality by reaction of 1-(Morpholin-4-Yl)-2-(1,3,4-Oxadiazol-2 yl-sulfanyl) Ethanone with various aromatic aldehyde giving Schiff base, The synthesized compounds were confirmed by 1HNMR, IR, element analysis and Mass spectroscopy. All the compounds were screened invitro antibacterial and antifungal activities. The minimum inhibitory concentration (MIC) was determined by the cup plate method. Ciprofloxacin was employed during the test procedures as reference. The MIC of the synthesized compounds ranges between 25-200 µg/ml. SMf were found moderately active compared with standard. Test compounds were found to be more sensitive towards Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria).And for the antifungal activity MIC of the synthesized compounds ranges between 15.6-500 µg/ml. SMf was found moderately active compared with standard. Test compounds were found to be more sensitive towards Aspergillu snigerand Candida  albicans.
Keywords: Saraca indica, Soxhlet, Hexane extract, Steroid.

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