Wednesday , 2 December 2020

Investigation of Antidiabetic Activity and Antioxidant Activity of Moringa Oleifera in Rats

Ramoju Madhuri1, Nagaraju, M.Kulkarni2, Murali Sollu3, Gampa Vijay Kumar4 
1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2Associate Professor, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
3Assistant Professor, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
4Professor and Head Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

ABSTRACT
Plants have been used as source of drugs for the treatment of diabetes mellitus in developing countries where the cost of conventional medicines represents a burden to the population. Many species have been reported to present antidiabetic activity. Moringa oleifera is a plant traditionally used for the treatment of diabetes mellitus. This dissertation was designed based in the traditional claim to emphasize the antihyperglycemic, antioxidant potential of the ethanolic extract of Moringa oleifera.  Preliminary phytochemical analysis of the EEMO extract of leaf of the plant showed that the plant has a rich possession of phytochemicals like flavonoids and steroids. In the sub-acute study, a steady decrease in blood glucose level was observed on EEMO treatment in Alloxan induced diabetic rats. The treatment of EEMO showed marked increase in body weight, marked increase in protein, HDL cholesterol levels in serum of Alloxan induced diabetic animals. EEMO has high scavenging activity against DPPH free radical generating system so it is considered to be a anti-oxidant. Based on the obtained results and observations, we can infer that the Moringa oleifera could be used for the supportive treatment of diabetes mellitus, as the plant also offers effective protection against free radicals that form the basis for the development of diabetic complications.
Keywords: Moringa oleifera, Antidiabetic activity, Anti-oxidant activity

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