Sunday , 4 December 2022

Formulation and In-Vitro Evaluation of Tacrolimus Solid Dispersions

Dr. Gampa Vijay Kumar1, Dr. V. Anjaneyulu2, G. Sonali3
1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
3KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
W. J. Pharm. Biotech., 2018, 5(2): 38-43

A B S T R A C T
“In the present study Tacrolimus solid dispersions were formulated the standard curve of Tacrolimus was obtained and good correlation was obtained” with R2 value 0f 0.999.the medium selected was pH 7.4 phosphate buffer. “Tacrolimus was mixed with various proportions of excipients showed no colour change at the end of two months proving no drug excipient interactions”. The precompression mix of Tacrolimus solid dispersions were characterized with relevance angle of repose, bulk density, broached density, Carr’s index and Hausner’s magnitude relation. The   precompression mix of all the batches indicating sensible to truthful flow ability and squeezability. Solid dispersions were ready with varied concentrations of carriers, the ready solid dispersions were compressed into pills by exploitation rotary tablet punching machine, and eight millimeter punch, with the hardness of four.5kg /cm2.The developed tablets were evaluated for varied internal control parameters. The tablets were passed all the tests. Among all the formulations F1 formulation containing, Drug and Peg 4000 within the magnitude relation of 1:0.25 showed sensible result that’s ninety four.95 you bored with fifty minutes. Because the concentration of compound will increase the drug unleashes was faded. Whereas the formulations containing PEG 6000 showed less unleash. Therefore from the dissolution knowledge it absolutely was evident that F1 formulation is that the higher formulation.
Keywords: Tacrolimus, solid dispersions, PEG 4000, PEG 6000.

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