Evaluation of Hepatoprotective Activity of Ethanolic Extracts of Caesalphania Bonducella using In-vivo Models

¹Dr. Gampa Vijay Kumar, ²Murali Sollu, ³Methari Jothsna Rani
¹Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
²Professor KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
³KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
W. J. Pharm. Biotech., 2018, 5(2): 44-49

A B S T R A C T
The present study has been designed to achieve the following aims and objectives. To evaluate the hepatoprotective activity of Caesalpinia bonducella on AZathioprine induced oxidative stress in mice. On the basis of our findings, it may be worthy to suggest that Caesalpinia bonducella has antioxidant activity against Azathioprine induced oxidative stress in mice by decreasing the oxidative stress biomarkers serum AST, serum ALT in liver Caesalpinia bonducella has antioxidant effect, elevated by measuring antioxidant enzymes. There is increase in superoxide dismutase in liver tissue in standard and test extracts treated mice. Caesalpinia bonducella has hepatoprotective effect against Azathioprine induced toxicity in liver by observing the histopathological changes in rat liver tissue.
Keywords: Caesalpinia bonducella, Azathioprine etc.