Sanjay K. Sharma*, Md. Nawaz Alam, Manish Jaimini, Arindam Chatterjee, Shailender Mohan
Department of Pharmaceutics, Jaipur College of Pharmacy, ISI-15, RIICO, Sitapura Institutional Area, Sitapura, Jaipur (Raj.), India.
An attempt was made to formulate the fast disintegrating dosages form of Zaltoprofen using various superdisintegrants viz. sodium starch glycolate, croscarmellose sodium and crospovidone. FD tablets containing 80 mg of Zaltoprofen were developed with microcrystalline cellulose as binder and manitol as sweetener. The tablets were prepared by wet granulation method. The formulations were optimized on the basis of acceptable weight variation, friability, hardness properties and in vitro drug release. The results of dissolution studies suggested that formulations F9 exhibited maximum release. Applying the linear regression analysis and model fitting, the selected formulation F9 have showed diffusion (non-fickian) release mechanism, and shown to follow Higuchi release kinetics.
Keywords: Zaltoprofen, Fast Disintegrating Tablets, wet granulation method, in-vitro dissolution, release kinetic models.